BNIP3 Interacting with LC3 Triggers Excessive Mitophagy in Delayed Neuronal Death in Stroke
نویسندگان
چکیده
منابع مشابه
BNIP3 upregulation and EndoG translocation in delayed neuronal death in stroke and in hypoxia.
BACKGROUND AND PURPOSE Delayed neuronal death is a hallmark feature of stroke and the primary target of neuroprotective strategies. Caspase-independent apoptosis pathways are suggested as a mechanism for the delayed neuronal injury. Here we test the hypothesis that one of the caspase-independent apoptosis pathways is activated by BNIP3 and mediated by EndoG. METHODS We performed immunohistoch...
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ژورنال
عنوان ژورنال: CNS Neuroscience & Therapeutics
سال: 2014
ISSN: 1755-5930
DOI: 10.1111/cns.12325